As we close out the year, we want to share a reflection that goes beyond a seasonal greeting. For Fundación Epistemonikos, year-end is also an institutional exercise: acknowledging what we have learned, thanking those who make this work possible, and clearly sharing where we are headed.

Our mission remains the same: to support decision-making in health and public policy with evidence that is reliable, accessible, and usable. Along this path, we continue to consolidate our Sustainable Knowledge approach: producing, organizing, and updating knowledge with standards of quality, efficiency, and minimal redundancy.

Internal progress: what we strengthened this year

Throughout 2025, we focused our efforts on improvements and capabilities that support our long term work:

• Tools and platforms for more efficient and traceable evidence synthesis

We continued strengthening workflows and components that support the evidence synthesis process, from organizing and classifying the literature to its visualization and use, with a focus on efficiency, traceability, and scalability. In this context, one of our major advances was opening Database of Trials (ED-Trials) to the public, our repository of health-related randomized controlled trials. ED-Trials helps address the fragmentation of evidence globally by consolidating multiple sources into a single, reliable resource, with continuous updates and open access.

• Usability and access: evidence that is more “usable” for different audiences

We advanced improvements aimed at making evidence products easier to explore, understand, and apply: better navigation, clearer structures, and formats that reduce friction for users with diverse needs. Within this framework, iES (Interactive Evidence Synthesis) allows us to present evidence products interactively, incorporating charts, tables, and images, and to clearly display different versions of the same work as it is updated over time. This strengthens change traceability and improves the end-user experience.

Along the same lines, BIGG Map reflects these improvements in how people navigate and visualize evidence and recommendations: more orderly exploration, clearer interfaces, and an experience that helps users find, understand, and connect relevant information for decision making.

• Methodological standards and responsible scientific communication

In a high velocity information environment, we maintained a core commitment: communicating evidence rigorously, making limitations and uncertainty explicit, and prioritizing transparency in our processes.

• Training and knowledge transfer

We consolidated training and support spaces to strengthen capacity in evidence synthesis and critical appraisal, with an emphasis on applied skills: how to select, interpret, and communicate findings using reproducible standards.

Joint work: continuity, new partnerships, and applied learning

This year, we strengthened ties with long standing collaborators and established new partnerships that enable us to advance the development of tools and approaches aimed at more sustainable and accessible evidence. We undertook demanding projects that, in addition to addressing needs across different contexts, helped us improve internal processes and consolidate ways of working that we seek to make transferable and reproducible for other teams. That combination, continuity, new collaborations, and applied learning, has been key to sustaining our mission and clearly projecting what comes next.

Acknowledgements

None of this would be possible without the team that sustains the work day to day: a group that combines technical excellence, commitment, and a collaborative culture reflected in every deliverable. Likewise, thank you to our global network of collaborators, who discuss, provide context, and challenge our ideas, because without that community we could not expand our ambition or move forward with the standard we strive for. Thank you for the professionalism, energy, and generosity with which you push this work forward, even when the challenge is significant.

What’s ahead in 2026: priorities

Looking to 2026, we know it will be a year of important challenges and internal goals: new releases, product improvements, and capability building that strengthen our contribution to evidence informed decision making. We approach that horizon with conviction, but also with a grounded sense of reality, prioritizing quality, transparency, and sustainability at every step.

Concretely, next year we will focus on:

• More accessible and actionable evidence, with improved visualization and navigation formats.

• Sustainable updating and maintenance, reducing duplication and increasing efficiency.

• Responsible AI applied to synthesis, with clear safeguards (governance, equity, transparency, and data sovereignty).

• Greater collaboration and knowledge transfer, connecting evidence with public policy and clinical practice needs.

• And, especially, strongly advancing work on E2E and SK Platform projects soon to be released designed to strengthen an end-to-end approach to generating, updating, and delivering evidence to end users.

We close the year with gratitude and a renewed commitment: to ensure that high quality evidence becomes increasingly useful, timely, and sustainable for those who need it.